We provide unique Work Loop models for the assessment of inotropy in human cardiac muscles and myocytes, directly measuring minute changes in the force of contraction.
We have received multiple grant awards and are currently engaged in a 3-year, NC3R/InnovateUK project to miniaturise the Work Loop platform.
Work Loop models are considered the gold standard of inotropy measurement. We manipulate heart muscle and myocytes to simulate the heart's natural movements whilst simultaneously measuring the force generated.
Work Loop shapes can provide insight into a drug's mode of action.
InoCardia's sarcomere shortening model offers a higher throughput means to identify inotropy in a test drug. Contractile length and speed changes due to drug are rapidly assessed, ranked and compared to known substances.
Our scientific team have wide expertise and knowledge in the safety pharmacology field. Need to find out more about your experimental drugs? Get in touch with us.
InoCardia's labs and offices are sited in Coventry, UK
During 2018 we will be moving into a new, purpose built laboratory and office facility. Fit out is expected to begin in the second half of 2018.